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Phenibut Dosage & Safety

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When we talk about Phenibut, the two most common questions we get involve dosage and safety. This guide will help both Phenibut veterans and newcomers better understand the safety and optimal Phenibut dosage.

What is Phenibut?

Phenibut is a naturally derived nootropic supplement, that, like the neurotransmitter GABA, has the ability to lower anxiety and provide a feeling of calmness. It has nearly the same structure of Baclofen (lacking only a chlorine atom in the para-position of the phenyl group) and holds Phenethylamine in its structure. Phenibut was produced in Russia at the USSR Academy of Medical Sciences in the 1960’s and was included in Russian astronauts’ health kits in 1975 as an anti-stress and anti-anxiety compound to be taken without influencing performance [1].

Phenibut Dosage and Safety Tips

Though the chemical structure of Phenibut is similar to the GABA molecule, it has a phenyl ring, which enables your Phenibut dosage to cross over the blood-brain barrier (BBB). GABA itself does a poor job of crossing the BBB when it is consumed in oral supplement form.

Phenibut is thought of as a high-powered supply system for GABA and is able to generate changes in the central nervous system. GABA plays a crucial role in the brain. So, you should be careful with your Phenibut dosage quantity or schedule. Otherwise, it may throw off the optimal performance of your cognitive faculties.

Phenibut Dosage & How To Use

One important thing you must remember once you have decided to take Phenibut is that it is a very powerful nootropic supplement. So, proper care and consideration must be needed to go into planning your dosage schedule.

A low dosage will be around 250-350 mg. This lower dosage offers a mild mood increase and feeling of calmness. It is also said that this lower dose improves sociability.

For experienced users, a higher dosage between 500 – 750 mg can be taken 2x a day. At this higher dosage, you still will get the mood-lift and calm sensation, and some increased sociability.  In addition, it also helps you with a healthy sleep throughout the night.

However, it is always advisable for new users to start with their lowest effective dosage. Brand new users will likely feel effects at less than 250mg. As always, individuals will react differently based on their genetics, epigenetics, and other variables. So, you should play it safe and start with a low dose.

It is not recommended to exceed the maximum Phenibut dosage of 1000 mg per split, or 2000 mg a day. Otherwise, you risk a chance of experiencing withdrawal and other negative side-effects. So, go slowly and carefully; first, monitor the effects at lower levels before considering raising your Phenibut dosage.

It is recommended to cycle Phenibut. Consider taking breaks from it to give your brain time to return to homeostasis. It is recommended to not use it more than twice a week. This can ensure that your body is not getting accustomed to it. Long-term use may lead to tolerance and withdrawal syndromes.

Benefits of Phenibut

Any dose in the 250-500 mg range will help lower stress levels and lessen anxiety. Anxiety generally is caused by overactive neuron activity which is caused by over-stimulation of certain neural pathways. Phenibut is thought to possess the capacity to soothe the excessive neuron firing.

Many users claim that their Phenibut has helped them to improve some of their cognitive abilities. These include enhanced memory and an expanded learning capacity, as well as the ability to remember memories and details more easily and quickly. Some evidence shows Phenibut is able to support enhanced neuronal communication between both hemispheres of the brain. It is also considered to help guide you to enhanced problem-solving abilities and more creative thought.

One of the interesting benefits of Phenibut is improved sleep. It is taken by many users as a sedative and they find it easier to be relaxed. These users then wake up with a feeling more rested and refreshed. It can be used as a substitute for strong sleeping pills.

Phenibut Side Effects

Phenibut is safe in its controlled use. Still, there might be some mild side effects of using a higher dosage and they can include stomach cramps or an upset stomach, dizziness, tiredness, lethargy, and short-term memory reduction. These are the usual side-effects with the use of all GABA-like substances. If Phenibut is used long-term, it can lead to dependence because of an increased tolerance. When a user withdraws suddenly, some withdrawal symptoms are also probable. The withdrawal symptoms include panic attacks, insomnia, irritability, and muscle spasms.

No matter which dose you choose, you will experience a very strong and sour taste. However, as it is water soluble you can mix the powder with water or juice. Others chose to encapsulate it.


  1. Slava Lapin(30 July 2009). From the Inside. Luniver Press. p. 209. ISBN978-1-905986-11-8.


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