One of the symptoms of aging is a decline in mitochondrial-supported bioenergetics and an increase in oxidative stress. The result is the familiar decrease in energy that comes with getting older. The combination of ALA + ALCAR acts as an anti-aging super team. This combination works by reducing oxidative stress, increasing mitochondrial biogenesis, and improving vascular function.[i]
And it is not just older people who benefit from this combo. Mitochondrial decay is a natural process that occurs to all individuals. So taking this supplement can help to stave off the inevitable energy decline that comes with age. And even young individuals often feel a pronounced energy boost.[ii]
Alpha Lipoic Acid (ALA) is a powerful antioxidant and an essential element of aerobic metabolism in the human body. It is often found in anti-aging supplements due to its ability to reduce inflammation and neurological decline. It is also found to protect against heart disease, diabetes, and liver disease.[iii]
One large study showed improvements in diabetic neuropathy.[iv] This appears to be more effective than other options for reducing nerve pain associated with diabetes.
The reduction in so many age-related issues makes ALA more than an antioxidant. It is an essential anti-aging superstar.
Acetyl L-Carnitine (ALCAR) is a superior absorbing version of the naturally occurring amino acid L-Carnitine. ALCAR produces energy in the mitochondria of the cell. This increase in energy is the mechanism thought to improve mental cognition. ALCAR is often used to combat issues like chronic fatigue and neurological decline.
While the effects of ALCAR for neuroprotection are well known,[v] current studies are taking place to see if it may actually promote an increase in peripheral nerve regeneration.[vi] This would be a major benefit for those who are suffering from peripheral neuropathy.
[i] Mcmackin CJ, Widlansky ME, Hamburg NM, Huang AL, Weller S, Holbrook M, Gokce N, Hagen TM, Keaney JF, Vita JA. Effect of Combined Treatment With α-Lipoic Acid and Acetyl-L-Carnitine on Vascular Function and Blood Pressure in Patients With Coronary Artery Disease. The Journal of Clinical Hypertension. 2007;9(4):249–255. doi:10.1111/j.1524-6175.2007.06052.x
[ii] Aliev G, Liu J, Shenk JC, Fischbach K, Pacheco GJ, Chen SG, Obrenovich ME, Ward WF, Richardson AG, Smith MA, et al. Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats. Journal of Cellular and Molecular Medicine. 2008;13(2):320–333. doi:10.1111/j.1582-4934.2008.00324.x
[iii] Gomes M, Negrato C. Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases. Diabetology & Metabolic Syndrome. 2014;6(1):80. doi:10.1186/1758-5996-6-80
[iv] Ziegler D, Low PA, Litchy WJ, Boulton AJM, Vinik AI, Freeman R, Samigullin R, Tritschler H, Munzel U, Maus J, et al. Efficacy and Safety of Antioxidant Treatment With -Lipoic Acid Over 4 Years in Diabetic Polyneuropathy: The NATHAN 1 trial. Diabetes Care. 2011;34(9):2054–2060. doi:10.2337/dc11-0503
[v] Zanelli SA, Solenski NJ, Rosenthal RE, Fiskum G. Mechanisms of Ischemic Neuroprotection by Acetyl-l-carnitine. Annals of the New York Academy of Sciences. 2008;1053(1):153–161. doi:10.1111/j.1749-6632.2005.tb00021.x
[vi] Curran MWT, Olson J, Morhart M, Sample D, Chan KM. Acetyl-L-carnitine (ALCAR) to enhance nerve regeneration in carpal tunnel syndrome: study protocol for a randomized, placebo-controlled trial. Trials. 2016;17(1). doi:10.1186/s13063-016-1324-2