Tianeptine Sodium

Rated 4.76 out of 5 based on 25 customer ratings
(28 customer reviews)


Pure tianeptine sodium powder packaged in a temperature controlled, resalable pouch or glass vial while supplies last. Tianeptine sodium is now available in 5, 10, and 20 grams.

View our Tianeptine Sodium Certificate of Analysis.



Tianeptine Sodium users know that finding a source of pure tianeptine sodium powder can be tough. We have searched tirelessly to find the tianeptine sodium of the highest quality available. We archive all Certificate’s of Analysis (COA) for every Lot Number. If you would like to see the COA for your Lot Number, just ask us. We believe in full transparency, and our customers know that they’re getting nothing but the best when they order tianeptine sodium from Supplements for Work.

Our Tianeptine Sodium is available in quantities of 5 grams, 10 grams, and 20 grams. Please note that we recently switched from the amber glass vials to safe and easy to use pouches which allow for much more accurate tianeptine sodium measurement.

Tianeptine Sodium Benefits

Tianeptine (also known as Stablon and Coaxil) is an atypical antidepressant used to treat major depressive disorder and off-labelhas been used to treat anxiety, asthma, and irritable bowel syndrome. Despite having the structure of a tricyclic antidepressant, the mechanism with which it exerts its effects is entirely different than the molecules with which it shares its structural backbone. It’s novel antidepressant and anti-anxiety action make it an especially versatile nootropic that has several possible uses.

The structure of Tianeptine

Early studies of Tianeptine Sodium made the mistake of classifying it has a Selective Serotonin Re-uptake Enhancer (SSRE), due to observations that repeated administration of the drug to rats produced a decrease in free serotonin without any change to serotonin release. In the intervening years since those first studies, this, however, has been proven to be an inaccurate assessment of the drug’s mechanism of action.[i] These results have never been duplicated and, in fact, neither Tianeptine nor its two primary metabolites have shown any direct effect on serotonin release, uptake, or binding in rat models.[ii]

For a long time after the realization that tianeptine did not affect the serotonin system, there was no accepted model of how it exerted its antidepressant and anti-anxiety effects. Despite having an unknown mechanism of action, the interim decades contained several basic scientific and clinical trials that proved the efficacy of tianeptine as a treatment for depressive symptoms. It wasn’t until 2014 when researchers funded by the National Institute of Health finally found what made tianeptine work: it is a full agonist of the human μ-opioid receptor (MOR) and a full agonist of the ϕ-opioid receptor (DOR), although at much lower potency than MOR.i The authors use this result to hypothesize that MOR activation (or possibly the dual activation of MOR and DOR) is the initial molecular event that is responsible for all of the downstream modulations which, in turn, exhibits antidepressant/antianxiety effects.

One example of the downstream effects that MOR activation has is the modulation of glutamatergic neurons in the dentate granule of the hippocampus. These specific neurons have been shown to be involved in stress responses, with their over-activation leading to more severe symptoms of stress.[iii] MOR activation in this region of the brain has been shown to decrease an enzyme which controls the number of NMDA receptors, the primary receptors that respond to glutamate. This has the net effect of decreasing the effectiveness of glutamate in inducing stress. Tianeptine also disinhibits a different subset of glutamatergic neurons in the CA1 region of the hippocampus that have been shown to increase synaptic plasticity in the hippocampus. Strikingly these interactions with the glutamatergic systems of the hippocampus bear striking similarities to how NMDA antagonists, such as ketamine, exert their antidepressant effects.

This is the hippocampus taken from a rat brain. While brain anatomy is a complicated subject, for this discussion it is important to realize that the same cells in different parts of the brain can have vastly different functions due to their circuitry.

While it may be alarming to learn Tianeptine acts on the same receptors as opioids, there is no need to fear: it seems to affect the receptor in an inherently different way. For instance, while tianeptine can act as a painkiller and produce reward responses, it does not result in tolerance or withdrawal except in extreme cases of abuse. While it should not be tried at home, there is even limited evidence that when morphine and tianeptine are co-administered, the tianeptine reduces the respiratory depression of the morphine without impairing the pain-killing effects.

Many people who make the decision to use tianeptine as a nootropic supplement report seeing a variety of benefits including better focus, mental and physical energy, and lifting of brain fog. However, there is great variance in the available reports and many mention the occurrence of side effects including headache, dizziness, trouble sleeping, drowsiness, dry mouth, and constipation.

While tianeptine produces significantly fewer cardiovascular, anticholinergic, sedative, and appetite-stimulating effects than other antidepressants, it has been found to possibly be more prone to causing liver damage than other antidepressants. It is worth noting that this research is still contested and not accepted as fact, but it is something to be aware of.

Tianeptine sodium is not FDA approved. Supplements for Work is not liable for any damages resulting from the use of its products. Learn more about our Terms of Service and Privacy Policy.



[i] Gassaway MM, Rives ML, Kruegel AC, Javitch JA, Sames D (2014). “The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonist”. Transl Psychiatry.

[ii] McEwen, BS; Chattarji, S; Diamond, DM; Jay, TM; Reagan, LP; Svenningsson, P; Fuchs, E (March 2010). “The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation”. Molecular Psychiatry.

[iii] Nasca C, Zelli D, Bigio B, et al. Stress dynamically regulates behavior and glutamatergic gene expression in hippocampus by opening a window of epigenetic plasticity. Proceedings of the National Academy of Sciences of the United States of America.



Additional information

Weight N/A
Dimensions 4 x 1 x 4 in

10 Grams, 20 Grams, 5 Grams

28 reviews for Tianeptine Sodium

  1. Rated 5 out of 5

    Steven Matthews

    Just an awesome overall experience. First, the quality is probably one of the best out there. Blows the garbage ND was selling out of the water… Received my package in just 2 days and I love the amber bottles. Perfect for discrete use because I can carry it in my pocket all day and no moisture gets in… I took a risk on a new vendor and I’m very happy to be one of their first satisfied customers.

  2. Rated 5 out of 5

    Jason Smith

    I ordered the Tianeptine Sodium from these guys through eBay before this website was up and tests show that this is extremely pure (I am not going to provide percentages yet because there is still work to be done). I agree with the above review by Steven Matthews that this blows NewMind out of the water considering they seem to cut their sodium with the free acid and possibly sulfate. Also, I love the amber vials. Once I empty the vials I know of about 20 different uses for them. Also, the service is nothing short of spectacular. I have been treated with the utmost courtesy and all of the questions I had were answered promptly and professionally. I won’t buy Tianeptine from any other business as long as Supplements for Work is around.

  3. Rated 5 out of 5

    Joshua C.

    I Ordered on eBay but was unable to leave feedback there due to the listing being down. The tianeptine that I received is the most effective batch that I’ve had in quite some time & I love the Amber vials! Maybe other vendors have inferior product, maybe it’s just my current physiology, either way it’s working very well for me. Stellar product, thanks!!

  4. Rated 3 out of 5

    Katie (verified owner)

    5 stars for the actual product but I feel obligated to give 1 star for the ordering/shipping. I ordered at an unfortunate time when their staffing wasn’t up to par. I emailed the email provided on this website (note to big guy: maybe it needs to be updated/changed?) 3 times in 4 days with no response whatsoever. I finally texted the number given on this site and got an immediate response. A LOT of back and forth for 4 days after that and was finally given the boss man’s number to contact. Yes, there was a lot of back and forth and frustration because no one seemed to know where my package was or if it had even shipped. HOWEVER, both Zach and Ryan were EXTREMELY pleasant and helpful the entire time. My package was eventually shipped out 9 days after I first ordered and I received it 2 days later (today).
    I didn’t get the tia in the amber vials like pictured :/ but it’s all good. I’m just glad I got the order lol. Thanks again guys. I’ll try you guys again soon.

    • Ryan

      Hi Katie,
      I’m glad you enjoyed our tianeptine sodium! Sorry again about the shipping and email issue, which again were both a result of a staffing issue that we have resolved and are now shipping all orders the same day and answering emails in 24 hours. We are also back in stock with the amber vials! I hope you come back again soon. Have a productive day.
      – Ryan from S4W

  5. Rated 5 out of 5

    Joshua (verified owner)

    Fast shipping. Very high quality product. Will be ordering again.

  6. Rated 4 out of 5

    Mark McDonald (verified owner)

    Had an issue with my shipping, but it was quickly fixed by these guys who more than made up for it. The tianeptine has to be the highest quality I’ve ever purchased.

  7. Rated 5 out of 5


    I did not encounter any shipping issues when I placed my first order as many others have reported (I’ve got no insight into the problem whatsoever), but what does stand out to me is the product quality – I dare say it’s absolutely phenomenal and the best available at this current time. If I don’t experience the reported shipping delays, receive good customer service, and continue receiving a quality product I will be ordering from S4W for the foreseeable future.

  8. Rated 5 out of 5


    Good quality tianeptine, up there with the highest quality nootropic vendors. There’s may be a bit less caustic. May replace my go to.

  9. Rated 5 out of 5

    Blake (verified owner)

    During my research I found it to it be a very pure product. The big plus was their awesome customer service. They will answer any questions you might have very promptly and clearly. Been a very good experience dealing with this vendor. Keep up the great work guys.

  10. Rated 5 out of 5

    Brent Brinzo (verified owner)

    Shipping issue like others have stated, but hopefully it’s fixed now. Was compensated for the error and the product is fantastic.

  11. Rated 5 out of 5

    Tyler Miller (verified owner)

    came quickly even with first class ship, tried and it seems legit! i thought it would ship from CA though and it didn’t… but it’s ok because the shipping was fast anyway.

  12. Rated 5 out of 5

    Barry Leeser (verified owner)

    One thing I cannot tolerate is poor customer service. When I have an issue with that I go somewhere else.
    Do not have to worry about that here. Great customer service, thank you for your quick fixes on any issues that arise. Great service great product.

    • ryan stabile (verified owner)

      Thanks, Barry! We like to let our customers shape our the future of S4W as we grow. Looking forward to providing you with awesome products and services for a long time to come.

      – Ryan
      CEO, Supplements for Work

  13. Rated 5 out of 5

    Geoffrey Floyd (verified owner)

    Product is quality and affordable, I chose 1 day Priority Express shipping and it came the next day! Great Service and quality product! Well worth making S4W your go to for all your supplement needs!

  14. KAlford (verified owner)

    Paid 25.00 for FedEx shipping, bc I didn’t want to use USPS due to their less than reliable service. Somehow my order was switched from FedEx to USPS (not by me and I have the order to prove I picked FedEx). Anyways received product, a bit caustic…waiting to see if it works.
    5 stars on having a phone number to have someone to contact, and for quick response to my emails. Still pondering why I paid 25.00 for FedEx but received USPS flat rate?

    • ryan stabile (verified owner)

      Hi KAlford,

      Your order was changed to USPS Express for 1 of 2 reasons: 1. You placed an order on a Friday or Saturday. Because FedEx does not deliver on Saturdays, we must change all orders to USPS Express so that we can have them delivered on time, or 2. FedEx does not provide overnight deliveries to some rural areas that don’t have an airport close by or aren’t easily accessibly from major highways. If your address fell in this category, FedEx wouldn’t accept your package at the time of pickup, so USPS was used to ensure a speedy delivery. FedEx might be more reliable – unless it’s a weekend! We no longer offer UPS or DHL because of their slow delivery times and mishandling of packages.

      Thanks for giving us 5-stars for customer service; we would also love to hear what you thought of the product.

      CEO, Supplements for Work

  15. Rated 5 out of 5

    Denjen (verified owner)

    I recently discovered this site in search of a new vendor since my previous vendor was outta stock. I place my order after 6 pm on August 3rd and by Monday august 7th I got my package. I got confirmation emails keeping me updated that my package was on its way. I was a little skeptical to order from here due to a few negative reviews but I can honestly say I’m glad I did. This vendor has the cheapest tianeptine sodium on market that I’ve come across so far. Anyways the product is A1 I love the vial it comes in better for scooping out and fillings my capsules. The packaging in itself sets this vendor apart from others. The glass vials are awesome way better then the pouch it usually comes in which makes a mess when you’re trying to scoop out the product. Well all and all I am very satisfied with this site and can say this will be my vendor from now on. S4w has my business.

  16. Rated 5 out of 5

    Boondock (verified owner)

    Now on my second order from S4W and I am ready to review their products! I always ensure I try something twice before giving a 5 star review, but I intended these 5 tars after order 1. I do have one negative comment which I will detail in the end (which is more preferential IMO).

    Why I ordered from here when already using other vendors: Simply put I found that Blue brain boot lickers tianeptine was horridly inconsistent and S4W commented on a reddit post of mine.

    Shipping Speed 4.95 stars – Both orders were shipped as the website advertises. I feel having placed my second order late on a Saturday that my package should have been out the door during the AM shipping on Monday, but I do not want to presume on the volume of orders they received that weekend. It was shipped in their evening shipping time which is perfectly acceptable. My first order was on a Monday before AM cutoff and overnight-ed, arrived next morning at 11am.

    Customer Service – Not had any issues requiring service so I cannot comment. Based on Ryans above comments and other users reviews it seems fantastic.

    Product 10 Stars – If you google tianeptine I have gotten it from almost all of the front page U.S. Vendors. S4W’s product is either on par or far better than all of those companies. I would say a determining factor then comes to pricing, shipping, containers, and customer service.

    This leads me to my only minor gripes. My first order of tianeptine arrived in a plastic bag inside a foil bag. Tianeptine sodium is an absolute pain to work with, and after dumping the powder I was forced to scrape much of the rest of the tianeptine off and there was still enough residue for a therapeutic research purpose. Not a big deal, but on my second order I also ordered 3 vials as I was in need of a viable container that would be reusable. Low and behold my tianeptine arrived in the highly loved vials so I feel a bit silly for having ordered the vials now. I am sure they will be just fine getting filled with my other powdered noots. My sodium also arrived separately from my sulfate, vials, and scale which is worth mentioning but matters not at all.

    Overall you can;t go wrong with these guys. I have now tried their sulbutiamine and after my next order of that stuff I will review as well but it is looking like it will be just as sparkely!

  17. Rated 5 out of 5

    Sam (verified owner)

    Love this nootropic and this company! Great service. The web chat is amazing as I spent several hours asking questions, getting live answers, etc. Bought several items. The tianeptine works like a charm. A+++++

  18. Rated 4 out of 5

    Robin (verified owner)

    Great product. I wish they would ship it in the amber vials though. I’ve ordered many times over the last 2 months and have yet to receive the amber vials. Shipping is awesome. Will order again.

    • ryan stabile (verified owner)

      Thanks, Robin! Glad you like our Tianeptine Sodium.

      In order to keep all of our products in stock, we sometimes have to use resealable foil pouches instead of the amber vials. While the bags are easier and quicker to process our products and ship them to customers, we always have at least one product that comes in amber vials. (most recently, this is 10 grams of tianeptine sodium) Unfortunately, right now it’s the luck of the draw as to whether you’ll receive an amber vial, clear glass vial, or the foil pouch, however, you can always purchase empty vials for just a few bucks and transfer your nootropics from bag to vial for easy storage and discrete use… we’ll take your feedback into consideration and try to stock more vials!

      Have a productive day,
      Ryan, CEO of S4W

  19. Rated 5 out of 5


    Hands down the highest quality product I have ever gotten, and I have tried just about every vendor on the web! I exclusively purchase from these guys now because I KNOW I’m getting the purest product. There is no variation in the quality, EVER. I have been ordering from then since February and each and every time the quality is top notch and the customer service is outstanding! These guys know their business, their product and their clientele! Super fast shipping which I can depend on EVERY. SINGLE. ORDER. I’m so thankful to have found them and I am a loyal client for life! Thank you guys for everything you do!

  20. Rated 5 out of 5

    L Mason (verified owner)

    I came to this site because New Mind lost their mind with that crazy form. Their loss was my gain. At first I was skeptical, but SfW is a stratosphere above NM in every way. After trying many vendors, SfW is my go-to based on quality and shipping times. Ryan’s customer service seems to be first-rate, too. The only issues I have are, it’s never available when I need it, and the vials. Absolutely hate those vials! Between static cling and only taking one ‘blast’ of humid air to totally wreck your day by gumming up the T’Pine in the vial, making it nearly impossible to get out. I just wish envelopes were an option in 10g sizes.

  21. Rated 5 out of 5

    SC Otto (verified owner)

    I’ve made several orders now, and I must say that you guys are by far a rock in the world of nootropics. I’ve been so impressed with the tianeptine as well as other products that I’ve shared them with my brother, sister in law, uncle. Now I have family members asking me to add on to my order each time I go to place one.

    The powder is such a pain to mess with, but so thrilled at the purity. The tianeptine is so pure that it is so easy for me to take the powder and make it a liquid suspension! Less-pure powders DO NOT liquid-suspend very well.

    Take a large glass dropper bottle, food grade propylene glycol, liquid peppermint extract, and some liquid stevia sweetener, do some math and measuring (a little heating and shaking)..and voila! A liquid Tianeptine Sodium suspension that can be carried around easily and administered precisely. Best of all, no messing with powder spills! Looking forward to my next order in the future!

  22. Rated 5 out of 5

    T-man (verified owner)

    Excellent product, fair pricing!!! Excellent packaging, excellent shipping. I was hesitant to try a new vendor, but New Mind lost my business. Thanks SFW! SO glad I found you.

  23. johnbrandy (verified owner)

    I was excited to find a sight that actually sold tianeptine sodim especially after my last go round with Blue Brain Boost and their fake tianeptine.With it becoming harder to find I had a feeling it might be too good to be true when I found this sight and read the reviews but I ordered anyways.Sure enough to my disappointment the product I received was a little bit of sodium mixed with a whole of something else.You have to take a lot of this to feel any effect.You should have a disclaimer stating that you dont get 100% tianeptine sodium but instead some sort of mix.

    • Eli

      Hi John,

      If you have any issues with your product, please send us a message via our contact form and we will be happy to remedy it for you.

  24. johnbrandy (verified owner)

    One more thing,Apparently only good reviews are used being that they have to be approved first.

  25. Rated 5 out of 5

    Haades (verified owner)

    Order for the first last week and everything went great. The Tianeptine Sodium was top-notch and everything I’ve learned to expect. Great mood lift and all around great feeling. Paid via BTC and the transaction was flawless. Tracking and shipping was on point and was updated every step of the way.

    Already placed another order with them and look forward to another great experience working with S4W. I’m glad I found this place and took the chance on them, was definitely worth it.

    Cheers guys

  26. Rated 5 out of 5

    David Elliott

    Made my first purchase with this vendor this evening. I ordered Saturday February the 17th at around 11:00pm. I will add to this regarding the experience and provide fair feedback/review of the product, shipping, customer service and packaging. I am looking for a place that has a stellar history that can deliver on very large orders. I will make a few orders at random and see how consistent they are. Seems good so far after looking over the most recent reviews.

    I hope it works out, we plan to use the next reputable company as our future supply source for our new line of nootropic stacks that will be hitting the market in late March if all goes well. This is the only thing we need at the moment is a consistent supplier for tianeptine sodium.

    Will be back to review the results

  27. Rated 5 out of 5

    Alisha Haas (verified owner)

    Extremely fast shipping, customer service is awesome, and everything was on point:)……Thank you S4W!!

  28. Rated 3 out of 5

    Don (verified owner)

    Have ordered several times now. I’d give this last order 5 stars; I’d love to keep being able to do so. Prices and product have always very good. Shipping has been from poor to terrible up until this last time I think I have tried all delivery methods except the overnight. Given my first couple times employing the added cost shipping I decided it made no difference whatsoever as to when I might get delivery so no use wasting my money. I’ve had things sit in their office for days and surprisingly had tracked packages sitting at their local USPS for days. Not sure what the issues have been, but this last time got my package In 2 days using free delivery so I’ll try it again in the future. The fact that I’ve continued to keep ordering speaks to their quality and pricing.

    I’m sure if they are reading my review and want to check they can go back and verify. I haven’t kept records myself. Something was different this time. Besides speedy turn around The tracking page looked different and the outer packaging was a little different. I hope whatever changes they’ve made address whatever was going on. If so I’d gladly give them an excellent/5 star rating and update my review.

    • Eli

      Hi Don, sometimes the USPS will not scan a package when they get it if they are extremely busy. This will cause the package to look like the USPS has not received it. You can always contact us about this and we will ask the USPS for a shipping refund for you have selected Priority or Express.

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